From the August 1971 magazine.

About Alcoholism - Alcoholism Information, Research and Treatment

The Laboratory Drunks

Dr. Dora B. Goldstein, a senior scientist in the pharmacology department [at Stanford University], devised a means of getting mice drunk on the fumes of alcohol. Mice had always seemed to be the best possible animal models for alcoholic tests, because they became alcoholic in two to four days, while more expensive animals might require two weeks. On the other hand, the mice eliminated alcohol from their systems so rapidly, many tests necessary to understanding addiction could not be made.

Dr. Goldstein devised a transparent, airtight plastic box into which alcohol vapors are pumped continuously. Twice a day, the mice are removed for weighing, blood-sample testing, and injecting a chemical to slow alcohol metabolism and assure a constant blood-alcohol level necessary for physical dependence. After a few days in the chamber, the mice are removed and tests taken to determine psychological responses during withdrawal.

-- Los Angeles Examiner

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