From the March 1973 magazine.

About Alcoholism - Alcoholism Information, Research and Treatment

'Tolerance Reversal'?

AMSTERDAM, NETHERLANDS--The tools currently available for preventing tolerance [of drugs such as barbiturates, alcohol, and minor tranquilizers] are crude and nonspecific, according to Addiction Research Foundation scientist Dr. Harold Kalant, but they represent the beginning of new approaches to the control of drug dependence.

Tolerance is nothing more than a decrease in sensitivity to the effects of a drug, he said, but it is not clear how this occurs. Of all the theories, most evidence suggests either that there is increased breakdown of the drug in the liver or other tissues, so that its duration of action in the body is shortened; or that the nervous system is altered in some way which makes it less sensitive when the drug actually reaches it.

-- The Journal (Addiction Research Foundation)

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